Flmodafinil NMR
Flmodafinil Overview
Flmodafinil, also known as CRL-40,940, is a synthetic eugeroic compound structurally related to modafinil and adrafinil. It has been explored in preclinical research for its wakefulness-promoting and vigilance-supporting properties. Flmodafinil is commonly discussed alongside other modafinil analogs due to shared structural features and overlapping pharmacological interest.
Flmodafinil is not approved for human or veterinary use and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
Flmodafinil is believed to promote wakefulness primarily through inhibition of dopamine transporter (DAT) activity, resulting in increased extracellular dopamine concentrations in brain regions associated with alertness and cognitive control. Similar to other eugeroic agents, secondary modulation of orexinergic and histaminergic signaling pathways has been proposed, though the precise mechanism remains under investigation.
Chemical Structure
Chemical Name: 2-[(Diphenylmethyl)sulfinyl]-N-(4-fluorophenyl)acetamide
Synonyms: Flmodafinil, CRL-40,940
Molecular Formula: C₁₅H₁₃F₂NO₂S
Molecular Weight: 309.33 g/mol
Structural Description: Flmodafinil contains a diphenylmethyl sulfinyl core linked to an acetamide moiety substituted with a para-fluorophenyl ring. This fluorinated aromatic substitution distinguishes it from modafinil and adrafinil and is believed to influence metabolic stability and central nervous system penetration.
Physical and Chemical Properties
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Appearance: White to off-white crystalline powder
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Solubility: Poor aqueous solubility; soluble in organic solvents such as DMSO and ethanol
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Stability: Stable under dry, cool, and light-protected storage conditions
Research Focus Areas
Flmodafinil is commonly examined in laboratory research related to:
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Wakefulness and vigilance models
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Cognitive performance and attention studies
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Comparative analysis with modafinil analogs
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Dopaminergic and arousal-related neurochemical pathways
Research Use Disclaimer
Flmodafinil is intended for research use only. Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
Flmodafinil (CRL-40,940) is a fluorinated eugeroic compound structurally related to modafinil and adrafinil. Its sulfinylacetamide framework and aromatic substitution pattern make it a compound of interest in wakefulness and cognitive research models.
| CAS Number | 90280-13-0 |
| Other Names | Bisfluoromodafinil, Lauflumide, CRL-40940, CRL-40,940, CHEMBL1672359, 174R2IG4T0, UNII-174R2IG4T0, SCHEMBL9217358, DTXSID00533646, BCP30574, BDBM50336897, AKOS028109855, s12271, Q21098952 |
| IUPAC Name | 2-[bis(4-fluorophenyl)methylsulfinyl]acetamide |
| Molecular Formula | C₁₅H₁₃F₂NO₂S |
| Molecular Weight | 309.33 |
| Dry-Fill Capsule Concentration | 50mg |
| Liquid Concentration And Solution | 50mg/mL PEG400, DMSO |
