What Is Alpha-GPC 50%?
Alpha-GPC 50% refers to a standardized powdered preparation of L-Alpha-Glycerylphosphorylcholine, typically spray-dried or adsorbed onto a carrier (commonly silica or calcium phosphate) to achieve 50% active Alpha-GPC by weight.
Alpha-GPC is a naturally occurring choline-containing phospholipid metabolite and a direct biosynthetic precursor to acetylcholine, making it a frequent subject of neurochemical, cognitive, and cholinergic signaling research.
Chemical & Technical Information
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Chemical Name: L-Alpha-Glycerylphosphorylcholine
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Common Name: Alpha-GPC
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Active Content: 50% (w/w)
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Molecular Formula (active): C₈H₂₀NO₆P
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Molecular Weight (active): 257.22 g/mol
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Appearance: White to off-white hygroscopic powder
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Solubility: Freely soluble in water
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Odor: Slight or characteristic
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Hygroscopicity: High (requires desiccated storage)
Note: The remaining 50% consists of inert carrier material used to stabilize the hygroscopic active compound.
Research Applications
Alpha-GPC 50% is widely used in non-clinical research environments involving:
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Choline bioavailability modeling
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Acetylcholine synthesis pathway studies
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Neurotransmitter turnover investigations
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Cognitive performance research models
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Neuromuscular signaling assays
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Phospholipid metabolism studies
Its high aqueous solubility and defined choline yield make it suitable for in vitro, ex vivo, and controlled laboratory formulations.
Why Use a 50% Standardized Form?
Using Alpha-GPC at 50% standardization offers several research advantages:
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Improved powder flow vs. pure Alpha-GPC
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Reduced hygroscopic clumping
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Easier gravimetric handling
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More consistent blending in dry matrices
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Enhanced stability during short-term storage
This format is especially useful in capsule fill simulations, powder blends, and solution preparation studies.
Handling & Storage Guidelines
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Store tightly sealed in a cool, dry environment
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Protect from moisture and humidity
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Use desiccants where possible
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Avoid prolonged air exposure during weighing
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Recommended storage temperature: 15–25°C
Due to its hygroscopic nature, Alpha-GPC should be handled quickly and resealed promptly.
Quality Control & Verification
Research-grade Alpha-GPC 50% is commonly verified using:
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HPLC for assay and purity
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Loss on drying (LOD) for moisture content
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Identity confirmation via reference standards
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Batch-specific COAs
Research Use Disclaimer
This product is not a dietary supplement, drug, or food additive.
For laboratory research use only (RUO).
Not intended for human or veterinary consumption.
| CAS Number | 28319-77-9 |
| Other Names | Glycerophosphorylcholine |
| IUPAC Name | 2-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxyethyl-trimethylazanium |
| Molecular Formula | C8H20NO6P |
| Molecular Weight | 257.223 g/mol |
| Dry-Fill Capsule Concentration | 350mg |
| Liquid Concentration And Solution | NA |
| Aliquot Concentration And Solution | NA |
