HBT1 (YDL233C) Overview
HBT1, also known by the screening identifier YDL233C, is a synthetic small-molecule AMPA receptor positive allosteric modulator. The YDL233C label originates from internal compound indexing during early screening and does not indicate yeast origin or biological derivation.
HBT1 has been studied in laboratory research for its ability to potentiate AMPA-type glutamate receptor (AMPAR) activity, making it a compound of interest in neuroscience research related to excitatory synaptic transmission and synaptic plasticity.
HBT1 is not approved for human or veterinary use and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
HBT1 functions as a positive allosteric modulator of AMPA receptors. It enhances glutamate-mediated AMPAR signaling without acting as a direct agonist. In research models, this results in:
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Increased AMPA receptor–mediated synaptic currents
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Prolonged receptor open time
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Enhanced excitatory neurotransmission
This mechanism places HBT1 within the broader class of AMPAkine-like compounds, though it represents a distinct chemical scaffold.
Chemical Structure
Chemical Name:
HBT1
Synonyms:
HBT1, YDL233C
Molecular Formula:
C₁₆H₁₃N₃O₂S
Molecular Weight:
311.36 g/mol
CAS Number:
489408-02-8
Structural Description:
HBT1 is a low-molecular-weight heterocyclic compound containing nitrogen- and sulfur-bearing functional groups. Its structure supports central nervous system penetration in experimental models and enables allosteric interaction with AMPA receptors. Structural identification and molecular data are available via PubChem.
Physical and Chemical Properties
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Appearance: White to off-white solid
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Solubility: Soluble in DMSO and common organic solvents; limited aqueous solubility
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Stability: Stable under dry, cool, and light-protected storage conditions
Research Focus Areas
HBT1 (YDL233C) is commonly examined in laboratory research related to:
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AMPA receptor modulation
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Excitatory synaptic transmission
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Synaptic plasticity and LTP models
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Neuropharmacology and cognitive signaling research
Research Use Disclaimer
HBT1 (YDL233C) is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
HBT1 (YDL233C, CAS 489408-02-8) is a synthetic small-molecule AMPA receptor positive modulator with a defined chemical structure and established use in neuroscience research. The YDL233C designation represents an internal compound identifier rather than biological origin. Its ability to enhance AMPAR-mediated signaling makes it a valuable tool for studying synaptic plasticity and excitatory neurotransmission.
| CAS Number | 489408-02-8 |
| Other Names | AKOS024270212, BS-47734, 2-[[2-[5-Methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide |
| IUPAC Name | 2-[[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide |
| Molecular Formula | C₁₆H₁₇F₃N₄O₂S |
| Molecular Weight | 386.39 |
| Dry-Fill Capsule Concentration | NA |
| Liquid Concentration And Solution | 20mg/ml, PEG400, DMSO |
| Aliquot Concentration And Solution | NA |
