Hydrafinil (Fluorenol) Overview
Hydrafinil, also known as Fluorenol, is a synthetic wakefulness-promoting compound structurally distinct from modafinil-class eugeroics. It belongs to the fluorene alcohol family and has been examined in laboratory research for its stimulant-like properties, alertness support, and effects on cognitive performance without direct amphetamine-like structure.
Hydrafinil is not approved for human or veterinary use and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
Hydrafinil is investigated for its effects on central nervous system arousal pathways. In research models, it is believed to influence dopaminergic signaling, primarily through interaction with dopamine transport mechanisms. Unlike classical stimulants, hydrafinil does not appear to function as a direct releasing agent but instead modulates neurotransmitter availability associated with wakefulness and attention.
Secondary interactions with adrenergic and histaminergic pathways have been proposed, though the precise mechanism of action remains under investigation.
Chemical Structure
Chemical Name:
9-Hydroxyfluorene (Fluoren-9-ol)
Synonyms:
Hydrafinil, Fluorenol
Molecular Formula:
C₁₃H₁₀O
Molecular Weight:
182.22 g/mol
CAS Number:
1689-64-1
Structural Description:
Hydrafinil is a fluorene-based aromatic alcohol consisting of a tricyclic hydrocarbon core with a hydroxyl group at the 9-position. This rigid polycyclic structure differentiates it from sulfinylacetamide eugeroics and contributes to its unique pharmacological research profile. Structural identification and molecular data are available via PubChem.
Physical and Chemical Properties
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Appearance: White to off-white crystalline solid
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Solubility: Poor aqueous solubility; soluble in organic solvents
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Stability: Stable under dry, cool, and light-protected storage conditions
Research Focus Areas
Hydrafinil (Fluorenol) is commonly examined in laboratory research related to:
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Wakefulness and alertness models
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Dopaminergic neurotransmission research
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Cognitive performance and vigilance studies
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Structure–activity relationships of fluorene derivatives
Research Use Disclaimer
Hydrafinil (Fluorenol) is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
Hydrafinil (Fluorenol) is a fluorene-derived wakefulness-promoting compound with a well-defined aromatic alcohol structure. Its distinct chemical scaffold and proposed dopaminergic modulation make it a compound of interest in laboratory research focused on alertness, cognitive performance, and stimulant mechanism exploration.
| CAS Number | 1689-64-1 |
| Other Names | 9H-Fluoren-9-ol, 9-Hydroxyfluorene, 1689-64-1, 9-Fluorenol, Fluoren-9-ol |
| IUPAC Name | 9H-fluoren-9-ol |
| Molecular Formula | C₁₃H₁₀O |
| Molecular Weight | 182.22 |
| Dry-Fill Capsule Concentration | 50mg |
| Liquid Concentration And Solution | 75mg/ml PEG400/DMSO |
| Aliquot Concentration And Solution | NA |
