Gonadorelin Overview
Gonadorelin is a synthetic decapeptide that is structurally identical to endogenous gonadotropin-releasing hormone (GnRH). It is a key regulatory peptide in the hypothalamic–pituitary–gonadal (HPG) axis and has been extensively studied in laboratory research focused on reproductive endocrinology and pituitary signaling pathways.
Gonadorelin is not approved for human or veterinary use in this context and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
Gonadorelin functions by binding to gonadotropin-releasing hormone receptors (GnRHR) located on anterior pituitary gonadotroph cells. Receptor activation triggers intracellular signaling cascades involving phospholipase C and calcium mobilization, leading to the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
In research models, gonadorelin is commonly used to study pulsatile hormone signaling, pituitary responsiveness, and regulation of the HPG axis.
Chemical Structure
Chemical Name:
Pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl-glycyl-leucyl-arginyl-prolyl-glycine amide
Synonyms:
Gonadorelin, GnRH, LHRH
Peptide Sequence:
pGlu–His–Trp–Ser–Tyr–Gly–Leu–Arg–Pro–Gly–NH₂
Molecular Formula:
C₅₅H₇₅N₁₇O₁₃
Molecular Weight:
1,182.26 g/mol
CAS Number:
33515-09-2
Structural Description:
Gonadorelin is a linear decapeptide featuring an N-terminal pyroglutamate residue and a C-terminal glycine amide, both of which are critical for receptor binding and biological activity. Its sequence and structure are identical to endogenous GnRH. Structural identification and molecular data are available via PubChem.
Physical and Chemical Properties
-
Appearance: White to off-white lyophilized powder
-
Solubility: Soluble in water and buffered aqueous solutions
-
Stability: Stable when stored lyophilized under cold, dry, and light-protected conditions
Research Focus Areas
Gonadorelin is commonly examined in laboratory research related to:
-
Hypothalamic–pituitary–gonadal axis signaling
-
Gonadotropin (LH and FSH) release mechanisms
-
Pituitary receptor sensitivity and pulsatile hormone models
-
Reproductive endocrinology research
Research Use Disclaimer
Gonadorelin is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
Gonadorelin is a well-characterized synthetic decapeptide identical to endogenous GnRH, with a clearly defined amino acid sequence and molecular structure. Its central role in regulating gonadotropin release makes it a foundational compound in reproductive and pituitary signaling research models.
| CAS Number | 33515-09-2 |
| Other Names | GONADORELIN, Dirigestran, Lutrefact, Relefact, Luforan, Lutamin, Lutal, Relisorm l, Synthetic LRF, Dirigestran Spofa |
| IUPAC Name | N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| Molecular Formula | C₅₅H₇₅N₁₇O₁₃ |
| Molecular Weight | 1182.3 |
