FOXO4-DRI is a synthetic research peptide. It is a modified version of the standard FOXO4 protein. Researchers study this peptide for its interaction with specific protein binding sites. The primary focus is on its role as a designed inhibitor of the FOXO4-p53 protein-protein interaction. Scientists apply it in in vitro models to examine how it competitively binds to p53. This research aims to map the molecular mechanisms of protein complex disruption. All work is conducted in controlled laboratory cell culture systems. The peptide serves as a tool for studying cellular senescence and apoptosis pathways. Kimera Chems provides this material strictly for non-clinical, investigative purposes.
Chemical Composition & Purity
The compound is available as a lyophilized powder. It appears to be a white to off-white solid. The molecular formula of the compound is C₂₂₈H₃₈₈N₈₆O₆₄. The compound’s molecular weight is 5358.05 g/mol. Kimera Chems confirms the identity and purity of the peptide (99%) using high-performance liquid chromatography (HPLC). It is done by third-party testing. This standard method confirms a purity level suitable for research.
Research Applications
In laboratory science, FOXO4-DRI peptide is used as a targeted protein-protein interaction inhibitor. Its design is based on mimicking a domain of the FOXO4 protein to compete for p53 binding. Scientists use it to examine the subsequent translocation of p53 from the nucleus in cultured cells.
- Protein Interaction Studies: For analyzing competitive binding to p53.
- Senescent Cell Models: Use in hydrogen peroxide or stress-induced cultures.
- Apoptosis Pathway Analysis: Examining caspase activation in specific cell types.
- Selectivity Assays: Researching effects on senescent versus normal cells.
- In Vitro Mechanism Research: Mapping downstream signaling events.
Storage & Handling Protocol
Correct storage is essential for preserving the integrity of this large, modified peptide. You must follow general laboratory safety and handling protocols.
- Lyophilized peptides can be kept at room temperature, away from direct light.
- If reconstituted, the sample should be kept in the fridge.
- For long-term storage, the material must be stored in the freezer.
- Store in a dry environment to protect from humidity.
- Always keep the powder in a tightly sealed vial.
- Use sterilized laboratory tools for all research measurements.
Compliance & Usage Disclaimer
This product is for Research Use Only (RUO). It is a chemical supplied exclusively for laboratory analysis and in vitro research. It is not for human or animal consumption. It is not a drug, dietary supplement, or cosmetic. Any material associated with a FOXO4-DRI peptide for sale listing is for approved research purposes only.
Availability & Research Sourcing
Kimera Chems is a reliable source for high-purity chemicals for the scientific community. You can buy foxo4-dri and other premium research chemicals from our website. We ensure that every batch meets the high standards required for research. We also provide detailed certificates of analysis to support your laboratory documentation.
| CAS Number | 2460055-10-9 |
| Other Names | Proxofim |
| IUPAC Name | (4R)-5-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-4-amino-1-[[2-[[(2R)-1-[[(2R)-1-[[(2R)-4-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[2-[[2-[[(2R)-6-amino-1-[[(2R)-1-[(2R)-2-[(2R)-2-[(2R)-2-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-6-amino-1-[[(2R)-6-amino-1-[[(2R)-5-carbamimidamido-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-[[(2R)-2-[[(2R,3R)-2-[[(2R)-2-[[(2R)-5-amino-2-[[(2R)-2-[[(2R,3R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-1-[(2R)-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R,3S)-2-[[(2R)-2-amino-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acid |
| Molecular Formula | C228H388N86O64 |
| Molecular Weight | 5358.05 |
