Roxadustat FG-4592

Roxadustat is a synthetic research compound. It is also known as FG-4592, ASP 1517, and Evrenzo. This compound belongs to the class of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors. The molecule contains an isoquinoline carboxamide structure. Investigators study this material to understand its interaction with prolyl hydroxylase enzymes. Research focuses on its binding characteristics and enzyme inhibition properties. Investigators buy FG-4592 to apply this compound in cell-free enzyme assays and in vitro models. They study its chemical properties and stability. This work is for mapping enzyme-inhibitor interaction pathways. All applications are within controlled laboratory environments. 

Chemical Composition & Purity

The product appears white to pale green in color. The molecular formula of this compound is C₁₉H₁₆N₂O₅. The molecular weight is 352.3 g/mol. Kimera Chems verifies each batch through third-party testing. High-performance liquid chromatography (HPLC) is used to confirm the identity and purity of FG-4592. The purity level is >98%, which is most suitable for research use.  Available formats:

• 5 grams powder
• 75 mg dry-fill capsules

Research Applications

Roxadustat binds to prolyl hydroxylase enzymes in isolated protein preparations. The molecule contains a glycine amide group that mimics natural substrates. This group fits into the enzyme’s active site, where oxygen binding normally occurs. The compound also has a phenoxy acetic acid moiety that stabilizes the interaction. In enzyme assays, researchers add Roxadustat to solutions containing prolyl hydroxylase and a labeled substrate. The compound occupies the substrate binding pocket. Scientists measure how much product forms compared to control samples. This helps determine binding strength. All the research is done in controlled in vitro settings. 

• Enzyme Binding: Measuring prolyl hydroxylase inhibition in cell-free assays.
• Competition Studies: Testing displacement of natural substrates.
• Binding Affinity: Determining inhibition constants using kinetic methods.
• Stability Testing: Monitoring degradation under various conditions.

Storage & Handling Protocol

If you’re looking for FG-4592 for sale, you should be aware of the standard lab guidelines for storing it properly to maintain its quality. 

• Store powder at room temperature in a sealed container for short-term storage. 
• Keep capsules in original packaging at room temperature.
• Protect the material from direct sunlight.
• Close the container tightly after each use.
• Use desiccant for powder storage. 

Compliance & Usage Disclaimer

This product is for laboratory research only. It is not for human or animal use. It is not a medicine or food supplement. Any roxadustat for sale is strictly for laboratory investigators. 

Availability & Research Sourcing

Kimera Chems provides high-purity materials for the global scientific community. You can buy roxadustat directly from our official website. We also offer this compound in multiple formats to support the research of scientists. For technical questions or bulk inquiries, contact our team today.