What Is Arimistane?

Arimistane, chemically known as Androsta-3,5-diene-7,17-dione, is a synthetic, non-steroidal aromatase inhibitor originally developed for experimental endocrine research. It is structurally derived from androstanes and functions as a suicide (irreversible) aromatase inhibitor in laboratory models.

Arimistane is not approved for human or veterinary use and is supplied strictly as a research-use-only (RUO) compound for qualified laboratories and investigators.

Chemical & Physical Properties

Property	Specification
Chemical Name	Androsta-3,5-diene-7,17-dione
Common Name	Arimistane
Molecular Formula	C₁₉H₂₄O₂
Molecular Weight	~284.39 g/mol
Chemical Class	Androstane derivative
Functional Category	Aromatase inhibitor (AI)
Appearance	White to off-white crystalline powder
Solubility	Soluble in DMSO, ethanol; limited solubility in water
Stability	Stable under dry, cool, light-protected conditions

Mechanism of Action (Research Context)

In in-vitro and preclinical models, Arimistane has been shown to:

Bind irreversibly to the aromatase (CYP19A1) enzyme
Inhibit conversion of androgens to estrogens
Reduce estrogen synthesis in controlled laboratory systems
Serve as a comparator compound in estrogen-pathway research

Because Arimistane acts as a suicide inhibitor, enzyme activity does not recover until new aromatase enzymes are synthesized—making it useful in mechanistic and duration-of-action studies.

Research Applications

Arimistane is commonly utilized in:

Aromatase inhibition assays
Estrogen pathway suppression studies
Endocrine signaling research
Androgen–estrogen balance models
Comparative AI research (steroidal vs non-steroidal)
Structure–activity relationship (SAR) analysis

All applications must remain non-clinical and non-consumptive.

Analytical Testing & Quality Control

High-quality Arimistane research material is typically verified using:

HPLC for purity and retention profile
Mass spectrometry (MS) for molecular confirmation
NMR spectroscopy for structural validation
Residual solvent analysis (when applicable)

Each batch should be traceable by lot number and accompanied by a Certificate of Analysis (COA).

Storage & Handling Guidelines

Store in a cool, dry environment
Protect from light and moisture
Recommended temperature: 2–8 °C for long-term storage
Handle with appropriate laboratory PPE
Avoid repeated exposure to ambient air

Regulatory & Compliance Status

Not a dietary supplement
Not a drug
Not approved for human or animal use
Sold strictly for research and laboratory purposes
Buyer assumes all responsibility for regulatory compliance

Frequently Asked Questions (FAQ)

Is Arimistane a steroid?

Arimistane is a synthetic androstane derivative, but it is not classified as an anabolic steroid in research literature. It is studied primarily for aromatase inhibition.

Is Arimistane orally bioavailable?

Bioavailability data exists only in experimental models. No approved human pharmacokinetic data exists.

Can Arimistane be used in vivo?

Only in approved, compliant laboratory research settings. It is not approved for clinical or consumer use.

Disclaimer

This product is sold for research use only (RUO).
Not for human consumption, medical use, or veterinary use.
All information provided is for educational and scientific reference purposes only.

CAS Number	1420-49-1
IUPAC Name	(8R,9S,10R,13S,14S)-10,13-dimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-7,17-dione
Molecular Formula	C19H24O2
Molecular Weight	284.17 g/mol
Dry-Fill Capsule Concentration	50mg

Arimistane