RAD-150 (TLB-150 Benzoate) Overview
RAD-150, also known as TLB-150 Benzoate, is a benzoate ester derivative of RAD-140 (vosilasarm / Testolone), a nonsteroidal selective androgen receptor modulator (SARM) originally developed by Radius Health and currently in active clinical development through Ellipses Pharma. Ester modification at the 2-hydroxy position of the parent RAD-140 scaffold yields a structurally distinct compound from the parent free hydroxyl form, with altered lipophilicity, hydrolytic behavior, and metabolic profile.
In laboratory research, RAD-150 is referenced in the broader context of ester-modified SARM investigations, including studies of androgen receptor (AR) ligand pharmacology, ester hydrolysis kinetics, and structure-activity relationships relative to non-esterified RAD-140 (vosilasarm).
RAD-150 is not approved for human or veterinary use and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action (Research Context)
RAD-150 is structurally a benzoate ester derivative of RAD-140. In experimental systems, ester compounds of this class are commonly studied as prodrug-like analogs that may undergo enzymatic hydrolysis to yield the corresponding parent hydroxyl compound. Receptor activity in research models is therefore primarily attributable to the hydrolyzed parent compound (RAD-140 / vosilasarm) rather than to a distinct receptor mechanism of the ester itself.
The benzoate ester is investigated primarily for its pharmacokinetic and metabolic differences relative to RAD-140, including:
- Increased lipophilicity and altered partition coefficient relative to the parent hydroxyl compound
- Modified hydrolytic and esterase-mediated metabolic conversion behavior
- Altered tissue distribution characteristics in published preclinical comparison work
- Comparative analytical and mass-spectrometric characterization alongside the parent compound
The compound is not characterized by a fundamentally different androgen receptor binding mechanism compared with RAD-140 once hydrolyzed; rather, the benzoate ester modification itself is the primary research interest.
Chemical Structure & Identification
- Chemical Name: (1R,2S)-1-[(3-Chloro-4-cyano-2-methylphenyl)amino]-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]propan-2-yl benzoate
- Synonyms: RAD-150; RAD150; TLB-150; TLB-150 Benzoate; RAD-140 Benzoate
- Chemical Class: Nonsteroidal benzonitrile-oxadiazole SARM — benzoate ester derivative
- CAS Number: 1208070-53-4
- Molecular Formula: C₂₇H₂₀ClN₅O₃
- Molecular Weight (average): 497.93 g/mol
- Exact Mass (monoisotopic): 497.126 g/mol
- PubChem CID: 162192581
Structural Description: RAD-150 retains the benzonitrile-oxadiazole scaffold of RAD-140 — a 2-chloro-3-methylbenzonitrile core, chiral (1R,2S)-configured propyl linker, and 5-(4-cyanophenyl)-1,3,4-oxadiazole heterocycle — with benzoylation of the central 2-hydroxy position to yield the corresponding benzoate ester. The molecular formula is consistent with the addition of a benzoyl group (+C₇H₄O) to the parent RAD-140 hydroxyl, increasing molecular weight from 393.83 (parent) to 497.93 g/mol (ester). Structural identification and molecular data are referenced against PubChem.
Note on chemistry verification: Researchers using RAD-150 for analytical reference or quantitative work should confirm identity by mass spectrometry against the molecular ion at m/z 497.1 (protonated species [M+H]⁺ ≈ 498.1), with characteristic loss of the benzoyl group (loss of 104 Da via benzoyloxy departure, or 122 Da via benzoic acid loss) yielding the parent RAD-140 fragment at m/z ≈ 393.8.
Physical and Chemical Properties
- Appearance: White to off-white solid
- Solubility: Increased lipophilicity relative to RAD-140 free base; soluble in DMSO and similar organic solvents; poorly soluble in water
- Stability: Stable under dry, cool, light-protected storage conditions; susceptible to ester hydrolysis under aqueous or basic conditions
- Recommended storage: -20 °C for long-term stability, protected from light and moisture
Research Focus Areas
RAD-150 is commonly referenced in laboratory research involving:
- Androgen receptor binding and signaling pathway studies in the context of ester-modified SARM pharmacology
- Comparative pharmacokinetic and metabolic studies between RAD-140 (vosilasarm) and its benzoate ester derivative
- Ester hydrolysis kinetics in plasma, hepatic, and intestinal esterase-containing systems
- Structure-activity relationship (SAR) analysis within the benzonitrile-oxadiazole SARM class
- Analytical method development and chromatographic separation of parent and metabolite species
- Forensic toxicology and metabolite identification research, with relevance to anti-doping analytical chemistry
Research Background & Regulatory Context
As a benzoate ester derivative of RAD-140 (vosilasarm), RAD-150 would yield RAD-140 upon hydrolysis. The parent compound RAD-140 is included on the World Anti-Doping Agency (WADA) Prohibited List under the anabolic agents category, and ester precursors that hydrolyze to listed substances are treated equivalently under WADA’s prohibited substance framework. The U.S. Food and Drug Administration has issued multiple public consumer advisories naming RAD-140 and related SARMs in the context of unapproved bodybuilding and dietary supplement products. The published literature on RAD-140 also includes case reports addressing hepatotoxicity and cardiovascular effects associated with non-medical use. This published regulatory and analytical record reinforces that RAD-150 is supplied strictly as a research reagent for laboratory and analytical use, not for any therapeutic, performance, dietary supplement, or other consumer application.
Research Use Disclaimer
RAD-150 (TLB-150 Benzoate) is intended strictly for laboratory research use only (RUO). Not for human consumption, clinical use, veterinary use, therapeutic application, dietary supplement use, or diagnostic purposes. All handling and use must comply with applicable federal, state, and local laws and institutional laboratory safety standards.
Summary
RAD-150 (TLB-150 Benzoate) is a structurally defined benzoate ester derivative of RAD-140 (vosilasarm / Testolone) with research utility in benzonitrile-oxadiazole SARM pharmacology, ester hydrolysis kinetics, and comparative metabolic and analytical studies. Its position as the benzoate ester of an actively-developing clinical-stage SARM makes it a useful reference compound for laboratory research into ester-modified AR ligand chemistry.
| CAS Number | 1208070-53-4 |
| Other Names | RAD150, RAD 150, TLB150, TLB-150, TLB 150, DTXSID40183806 |
| IUPAC Name | 2-[5-chloropentyl(methyl)amino]-N-(2,6-dimethylphenyl)acetamide |
| Molecular Formula | C₂₇H₂₀ClN₅O₃ |
| Molecular Weight | 497.94 |
| Dry-Fill Capsule Concentration | 10mg |
| Liquid Concentration And Solution | 20mg/ml (PEG400) |
| Aliquot Concentration And Solution | 30mg/ml (PEG400, Propylene Glycol, Benzyl Benzoate, Benzyl Alcohol) |
