What Is Bromantane?
Bromantane is a synthetic adamantane-derived compound originally developed in Russia and studied for its actoprotective, dopaminergic, and anxiolytic properties. Unlike classical stimulants, bromantane is notable for enhancing physical and cognitive performance without significant sympathomimetic overstimulation, making it a unique subject of interest in neuropharmacology and fatigue-resilience research.
Bromantane is sometimes referred to by its development name Ladasten, though it is more accurately described in research contexts by its chemical identity rather than trade nomenclature.
Chemical & Physical Properties
| Property | Value |
|---|---|
| Chemical Name | N-(4-bromophenyl)adamantan-2-amine |
| Molecular Formula | C₁₆H₂₀BrN |
| Molecular Weight | ~322.25 g/mol |
| Chemical Class | Adamantane derivative |
| Appearance | White to off-white crystalline powder |
| Solubility | Poor water solubility; soluble in organic solvents |
| Stability | Stable under dry, cool, and light-protected conditions |
Mechanism of Action (Research Overview)
Bromantane exhibits a multimodal mechanism distinct from traditional stimulants:
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Upregulation of tyrosine hydroxylase expression, increasing endogenous dopamine synthesis
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Enhanced dopaminergic tone without excessive dopamine release
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Mild anxiolytic effect, likely via indirect GABAergic modulation
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Actoprotective activity, improving endurance and resistance to fatigue without increased oxygen demand
Importantly, bromantane does not act as a classical dopamine releaser or reuptake inhibitor, which helps explain its lower incidence of jitteriness and rebound fatigue in animal models.
Research Applications
Bromantane has been investigated in preclinical and limited clinical literature for:
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Fatigue resistance and endurance modeling
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Stress-induced cognitive impairment
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Dopaminergic signaling modulation
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Psychomotor performance under load
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Anxiety-associated performance decline
Its ability to enhance performance while maintaining emotional stability makes it particularly interesting for central fatigue and stress-adaptation research.
Bromantane vs Traditional Stimulants
| Feature | Bromantane | Amphetamine-Like Stimulants |
|---|---|---|
| Dopamine Effect | Increases synthesis | Forces release |
| Anxiety | Often reduced | Often increased |
| Crash | Minimal | Common |
| Peripheral Stimulation | Low | High |
| Fatigue Rebound | Rare | Frequent |
Regulatory & Research Use Disclaimer
Bromantane is not approved for human consumption in many jurisdictions and is supplied strictly as a research chemical.
It is intended for laboratory and analytical research purposes only.
Not for diagnostic, therapeutic, or veterinary use.
Storage & Handling
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Store in a cool, dry environment
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Protect from light and moisture
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Use appropriate laboratory PPE when handling
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Maintain proper labeling and documentation for research compliance
Frequently Asked Questions
Is bromantane a stimulant?
Bromantane is not a classical stimulant. It enhances dopaminergic function through synthesis upregulation rather than forced neurotransmitter release.
Does bromantane cause tolerance?
Research suggests low tolerance development compared to traditional stimulants, though long-term data remains limited.
Is bromantane water soluble?
No. Bromantane has poor aqueous solubility and is typically dissolved in organic solvents for research purposes.
Summary
Bromantane is a chemically unique adamantane-based actoprotector with dopaminergic and anxiolytic properties that distinguish it from conventional stimulants. Its research value lies in fatigue resistance, stress adaptation, and cognitive-performance modeling without excessive sympathetic activation.
| CAS Number | 87913-26-6 |
| Other Names | Bromantan, Ladasten, bromontan, UNII-N1ILS53XWK, N1ILS53XWK, SCHEMBL737152, CHEMBL4303520, DTXSID40405333, AKOS004120981, AKOS037644786, AS-54469 |
| IUPAC Name | N-(4-bromophenyl)adamantan-2-amine |
| Molecular Formula | C₁₆H₂₀BrN |
| Molecular Weight | 306.24 |
| Dry-Fill Capsule Concentration | 50mg |
| Liquid Concentration And Solution | 50mg/ml (PEG400,DMSO) |
