Y134 Article
Y-134 Overview
Y-134 is a synthetic small-molecule selective estrogen receptor modulator (SERM) that displays high selectivity for the estrogen receptor α (ERα) over estrogen receptor β (ERβ), making it valuable in laboratory research focused on estrogen signaling, receptor pharmacology, and hormone-dependent cellular pathways. SCBT+1
In experimental studies, Y-134 has been shown to act as an agonist in bone tissue and an antagonist in reproductive tissues, with potent inhibitory effects on estrogen-stimulated cellular proliferation in ER-positive models. MedKoo Biosciences
Y-134 is not approved for human or veterinary use and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
Y-134 is studied as a selective estrogen receptor modulator (SERM). In research models, this activity is characterized by:
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High affinity binding to ERα with markedly greater selectivity than for ERβ
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Functional modulation of estrogen-dependent gene transcription
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Tissue-specific agonist and antagonist actions
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Utility as a probe for estrogen receptor signaling and hormone-dependent proliferation studies Tocris Bioscience
This selectivity allows dissection of ERα versus ERβ pathways in cellular and molecular models without broad steroid hormone receptor cross-reactivity. MedKoo Biosciences
Chemical Structure
Chemical Name:
(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(4-isopropylpiperazin-1-yl)phenyl)methanone
Synonyms:
Y-134, Y134
Chemical Class:
Selective estrogen receptor modulator (SERM)
Molecular Formula:
C₂₈H₂₈N₂O₃S SCBT
Molecular Weight:
472.60 g/mol SCBT
CAS Number:
849662-80-2 SCBT
PubChem CID:
11784736 Tocris Bioscience
Structural Description:
Y-134 is a benzothiophene derivative featuring a piperazine side chain and hydroxy substituents that enhance estrogen receptor interactions. Its scaffold is structurally related to raloxifene analogs but optimized for greater ERα selectivity in experimental research. Cayman Chemical
Physical and Chemical Properties
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Appearance: Yellow to off-white solid (reported supplier listings) ApexBio
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Solubility: Soluble in DMSO and ethanol at high concentrations Tocris Bioscience
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Stability: Stable under dry, cool, and light-protected storage conditions
Research Focus Areas
Y-134 is commonly examined in laboratory research related to:
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Estrogen receptor (ER) signaling and pharmacology
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Selective modulation of ERα versus ERβ pathways
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Breast cancer cell proliferation models
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Structure–activity relationship (SAR) of SERMs
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Hormone-dependent gene expression studies Tocris Bioscience
Research Use Disclaimer
Y-134 is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
Y-134 is a selective estrogen receptor modulator (SERM) with verified chemical identifiers:
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CAS: 849662-80-2 SCBT
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Molecular Formula: C₂₈H₂₈N₂O₃S SCBT
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Molecular Weight: 472.60 g/mol SCBT
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PubChem CID: 11784736 Tocris Bioscience
Its defined small-molecule structure and pronounced ERα selectivity make Y-134 a powerful research compound for studies of estrogen receptor biology and hormone-dependent signaling.
| CAS Number | 849662-80-2 |
| Other Names | Y 134; Y134; Y-134; Raloxifene Analog |
| IUPAC Name | 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone |
| Molecular Formula | C28H28N2O3S |
| Molecular Weight | 472.6 g/mol |
| Dry-Fill Capsule Concentration | 10mg |
| Liquid Concentration And Solution | 20mg/ml (PEG400,DMSO) |
| Aliquot Concentration And Solution | NA |
