Semax Overview
Semax is a synthetic heptapeptide nootropic originally developed in Russian research programs as a fragment analog of adrenocorticotropic hormone (ACTH 4–10), modified to eliminate hormonal activity while preserving neurotrophic and cognitive effects. It is widely studied in laboratory research for its influence on cognition, neuroplasticity, and stress-response signaling.
Semax is distinct from classical stimulants and racetams and is classified as a peptide-based neuromodulator.
Semax is not approved for human or veterinary use in this context and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
Semax is studied as a multimodal neurotrophic signaling peptide. In experimental research models, it has been reported to:
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Modulate brain-derived neurotrophic factor (BDNF) expression
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Influence neuroplasticity and synaptic signaling
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Affect dopaminergic and serotonergic pathways
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Regulate stress-response and adaptive neural signaling without ACTH-like endocrine effects
Its peptide structure allows it to act as a regulatory signal rather than a direct neurotransmitter agonist.
Chemical Structure
Chemical Name:
Semax
Synonyms:
Semax peptide
Peptide Type:
Synthetic heptapeptide
Peptide Sequence:
Met–Glu–His–Phe–Pro–Gly–Pro
Molecular Formula:
C₃₇H₅₁N₉O₁₀
Molecular Weight:
813.89 g/mol
CAS Number:
80714-61-0
Structural Description:
Semax is a linear heptapeptide composed of seven amino acids. The sequence is designed to preserve neurotrophic signaling while avoiding endocrine activity associated with full-length ACTH peptides. Structural identification and molecular data are indexed in PubChem and peptide supplier databases.
Physical and Chemical Properties
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Appearance: White to off-white lyophilized powder
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Solubility: Soluble in water and buffered aqueous solutions after reconstitution
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Stability: Stable when stored lyophilized under cold, dry, and light-protected conditions
Research Focus Areas
Semax is commonly examined in laboratory research related to:
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Cognitive function and memory signaling
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Neuroplasticity and synaptic modulation
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Stress-response and adaptive neural pathways
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Peptide-based nootropic and neurotrophic research
Research Use Disclaimer
Semax is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
Semax is a well-characterized synthetic nootropic peptide with verified chemical identifiers:
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CAS: 80714-61-0
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Molecular Formula: C₃₇H₅₁N₉O₁₀
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Molecular Weight: 813.89 g/mol
Its defined peptide structure and neurotrophic research profile make Semax a foundational compound for laboratory studies of cognition, neuroplasticity, and stress-related neural signaling.
| CAS Number | 80714-61-0 |
| Other Names | ACTH (4-7), Pro-Gly-Pro-ACTH (4-7), prolyl-glycyl-proline-Pro-Gly-Pro-ACTH (4-7) |
| IUPAC Name | (2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid |
| Molecular Formula | C₃₇H₅₁N₉O₁₀S |
| Molecular Weight | 813.9 |
