MK-777 (Acetamoren) Overview
MK-777, also known as Acetamoren, is a synthetic non-peptide small-molecule compound classified as a growth hormone secretagogue receptor (GHS-R1a) agonist. It is a proprietary research compound supplied as part of Kimera Chems’ research-reagent catalog, structurally related to the broader class of non-peptide ghrelin receptor ligands that includes ibutamoren (MK-677), capromorelin, anamorelin, and macimorelin.
MK-777 / Acetamoren is supplied as a research reagent for laboratory and analytical research purposes. As a relatively novel compound within the non-peptide GHS class, MK-777 has limited primary peer-reviewed literature coverage relative to established class members; researchers using this material should verify identity and characterize pharmacological parameters within their own experimental systems and against batch-specific Certificates of Analysis.
MK-777 is not approved for human or veterinary use and is not intended for therapeutic, dietary supplement, performance, or any other consumer application.
Mechanism of Action (Research Context)
MK-777 is classified as a non-peptide ghrelin receptor (GHS-R1a) agonist. By analogy to other characterized members of the non-peptide GHS-R1a ligand class, such compounds are typically studied for receptor binding, downstream signaling pathway activation, and structure-activity relationships within the ghrelin receptor ligand family.
Detailed pharmacological characterization of MK-777 specifically (binding affinity, receptor selectivity, downstream signaling, pharmacokinetics) should be confirmed by independent experimental work. Researchers working with MK-777 are encouraged to validate any reported binding or pharmacological parameters within their own assay systems and against established reference compounds in the same class.
Chemical Structure & Identification
- Synonyms: MK-777; MK777; Acetamoren
- CAS Number: 950841-87-9
- UNII: DHZ77GVH76
- Molecular Formula: C₂₉H₃₈N₄O₆S
- Molecular Weight: 570.70 g/mol
- Structural class: Non-peptide ghrelin receptor (GHS-R1a) agonist; small-molecule scaffold containing sulfonyl functionality
Note on chemistry: Identity should be confirmed by mass spectrometry against the molecular ion at m/z 570.70 (protonated species [M+H]⁺ ≈ 571.7) prior to use in any application requiring quantitative identity verification.
Physical and Chemical Properties
- Appearance: White to off-white crystalline powder
- Solubility: Soluble in DMSO and similar organic solvents; limited aqueous solubility
- Stability: Stable under dry, cool, light-protected storage conditions
- Recommended storage: -20 °C for long-term stability, protected from light
Research Focus Areas
MK-777 may be examined in laboratory research involving:
- Non-peptide ghrelin receptor (GHS-R1a) binding and signaling studies
- Comparative GHS pharmacology research alongside established class members (MK-677, capromorelin, anamorelin, macimorelin)
- Structure-activity relationship (SAR) analysis within the non-peptide GHS class
- In vitro receptor pharmacology and ligand displacement studies
- Analytical method development and chromatographic characterization
Storage & Handling
- Store in a cool, dry location; -20 °C recommended for long-term storage
- Protect from light and moisture
- Keep container tightly closed after each use
- Use appropriate laboratory handling procedures and PPE
Research Use Disclaimer
MK-777 (Acetamoren) is intended strictly for laboratory research use only (RUO). Not for human consumption, clinical use, veterinary use, therapeutic application, dietary supplement use, or diagnostic purposes. All handling and use must comply with applicable federal, state, and local laws and institutional laboratory safety standards.
| CAS Number | 950841-87-9 |
| Other Names | Acetamoren, MK-777 |
| IUPAC Name | Propanamide,2-(acetylamino)-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4′-piperidin]-1′-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-(ACI) |
| Molecular Formula | C29H38N4O6S |
| Molecular Weight | 570.7 |
| Dry-Fill Capsule Concentration | 10mg |
| Liquid Concentration And Solution | 20mg/mL, PEG400 |
| Aliquot Concentration And Solution | N/A |
