Aniracetam Overview
Aniracetam is a synthetic racetam nootropic compound originally developed in the 1970s and widely studied for its effects on cognitive performance, memory formation, and neurotransmitter modulation in experimental models. Structurally related to piracetam, Aniracetam is distinguished by its greater lipophilicity, allowing enhanced blood–brain barrier penetration in research settings.
In laboratory studies, Aniracetam has primarily been investigated for its interaction with AMPA-type glutamate receptors, classifying it as an ampakine-like modulator. This mechanism has made it of interest in cognitive, neuroplasticity, and synaptic transmission research.
For research use only. Not for human or veterinary consumption.
Chemical & Physical Properties
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Chemical Name: 1-(4-Methoxybenzoyl)-2-pyrrolidinone
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Molecular Formula: C₁₂H₁₃NO₃
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Molecular Weight: 219.24 g/mol
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CAS Number: 72432-10-1
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Compound Class: Racetam nootropic
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Solubility: Lipophilic; poorly soluble in water, soluble in organic solvents
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Appearance: White to off-white crystalline powder
Mechanism of Action (Research Context)
Aniracetam is primarily studied as a positive allosteric modulator of AMPA receptors, enhancing glutamatergic neurotransmission without directly activating the receptor. This modulation is associated with:
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Increased synaptic responsiveness
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Enhanced long-term potentiation (LTP)
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Improved signal transmission between neurons in experimental models
Secondary research suggests Aniracetam may influence dopaminergic and serotonergic signaling, though these effects appear indirect and remain under investigation.
Research Applications
Aniracetam is commonly used in in vitro and in vivo laboratory research involving:
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Cognitive performance modeling
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Memory and learning pathway analysis
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Neuroplasticity and synaptic efficiency studies
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AMPA receptor signaling research
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Nootropic structure–activity relationship (SAR) comparisons
Because of its fat-soluble nature, Aniracetam is frequently included in comparative racetam studies to evaluate pharmacokinetic and mechanistic differences across the racetam class.
Comparison to Other Racetams
Compared to first-generation racetams such as piracetam:
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Aniracetam demonstrates higher potency in AMPA modulation
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Exhibits shorter half-life in experimental models
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Shows greater lipophilicity, influencing distribution characteristics
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Often studied alongside oxiracetam and pramiracetam in nootropic research
Stability & Storage Guidelines
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Store in a cool, dry environment
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Protect from heat, moisture, and direct light
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Maintain container integrity to prevent degradation
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Intended for controlled laboratory settings only
Regulatory & Compliance Notice
Aniracetam is sold strictly as a research compound. No therapeutic, cognitive, or performance claims are made or implied.
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Not approved for human consumption
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Not a dietary supplement
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Not a drug product
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Research and laboratory use only
Frequently Asked Research Questions
Is Aniracetam water soluble?
No. Aniracetam is lipophilic and exhibits poor aqueous solubility, a key distinction from piracetam in research formulations.
What receptor systems are studied with Aniracetam?
Primarily AMPA-type glutamate receptors, with secondary interest in dopaminergic and serotonergic pathways.
Why is Aniracetam classified as an ampakine-like compound?
Due to its positive allosteric modulation of AMPA receptors rather than direct agonism.
| CAS Number | 72432-10-1 |
| Other Names | 72432-10-1, Draganon, Sarpul, Ampamet, Ro 13-5057, Aniracetamun, Memodrin |
| IUPAC Name | 1-(4-methoxybenzoyl)pyrrolidin-2-one |
| Molecular Formula | C₁₂H₁₃NO₃ |
| Molecular Weight | 219.24 |
| Dry-Fill Capsule Concentration | 375mg |
| Liquid Concentration And Solution | NA |
| Aliquot Concentration And Solution | NA |
