AC-262 Overview
AC-262,536 (also referenced as AC-262,356) is a nonsteroidal selective androgen receptor modulator (SARM) developed by Acadia Pharmaceuticals and investigated in receptor pharmacology research. As a small-molecule androgen receptor ligand, AC-262 has been characterized as a partial agonist with nanomolar affinity for the androgen receptor and limited cross-reactivity at other tested receptor targets.
Its defined receptor-binding profile and consistent signaling behavior have made AC-262 a frequently referenced compound in studies examining androgen receptor modulation, partial agonism, and structure-activity relationships across the SARM class.
Chemical Structure and Identification
Chemical Name: AC-262,536 Synonyms: AC-262,356; ACP-262; Accadrine IUPAC Name: 4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile CAS Number: 870888-46-3 PubChem CID: 44512434 Molecular Formula: C₁₈H₁₈N₂O Molecular Weight: 278.35 g/mol
AC-262 is structurally distinct from steroidal androgens and from arylpropionamide-class SARMs. Its scaffold combines a naphthalene-carbonitrile group with a tropane-like 8-azabicyclo[3.2.1]octane unit bearing a hydroxyl substituent. The molecule exhibits endo/exo isomerism, with the endo form reported as the active configuration.
Chemical identity and molecular data are referenced against PubChem.
Mechanism of Action
AC-262 binds directly to the androgen receptor and acts as a partial agonist, inducing a receptor conformation associated with selective transcriptional activity across androgen-responsive cell models.
Research characterizations describe:
- Direct binding at the androgen receptor ligand-binding domain
- Partial agonist activity with low-nanomolar receptor affinity
- Differential transcriptional output across androgen-responsive cell types observed in preclinical receptor signaling studies
- Minimal cross-reactivity at non-androgen nuclear receptors in published assays
This profile has supported AC-262’s use as a reference ligand in mechanistic androgen receptor research.
Research Applications
AC-262 is commonly utilized in laboratory research involving:
- Androgen receptor binding and signaling studies
- SARM structure-activity relationship (SAR) analysis
- Comparative androgen receptor ligand evaluation alongside other nonsteroidal SARMs
- Receptor conformational and transcriptional response models
- Molecular pharmacology research
Its consistent receptor-interaction profile supports its use as a reference compound in SARM-focused investigations.
Physical and Chemical Properties
- Form: Solid compound
- Solubility: Soluble in standard organic laboratory solvents (DMSO, polyglycols); poorly water-soluble
- Stability: Stable under controlled storage conditions; store protected from light at recommended temperatures
- Isomerism: Endo/exo isomerism reported in the literature
Preparation and handling methods depend on experimental design and solvent system.
Research Use Disclaimer
AC-262 is provided strictly for laboratory research use only (RUO). Not intended for human consumption, clinical use, veterinary use, or diagnostic purposes. All research involving this compound must comply with applicable laws and institutional guidelines.
Final Summary
AC-262,536 is a structurally defined nonsteroidal selective androgen receptor modulator with documented relevance in androgen signaling and SARM pharmacology research. Its naphthalene-carbonitrile/azabicyclic scaffold and partial agonist profile make it a useful reference compound for studying androgen receptor modulation in controlled laboratory settings.
| CAS Number | 870888-46-3 |
| Other Names | AC-262536, AC 262, AC262, AC 262536, AC262536, U8VS41J5O6, UNII-U8VS41J5O6, SCHEMBL4879625, SCHEMBL4881906, CHEMBL3084525, DTXSID701336168, EX-A4672, EX-A7097, MFCD24386408, AKOS040747750 |
| IUPAC Name | 4-[(1R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]naphthalene-1-carbonitrile |
| Molecular Formula | C₁₈H₁₈N₂O |
| Molecular Weight | 278.355 |
| Dry-Fill Capsule Concentration | 15mg |
| Liquid Concentration And Solution | 30mg/ml (PEG400) |
| Aliquot Concentration And Solution | NA |
