Tesamorelin Overview
Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) engineered to stimulate endogenous growth hormone (GH) secretion via the pituitary in experimental systems. It is a 44–amino acid peptide designed with structural modifications that enhance stability and biological activity compared to native GHRH.
In laboratory research, tesamorelin is examined for GH axis regulation, pituitary responsiveness, metabolic signaling, and endocrine pathway studies.
Tesamorelin is not approved for human or veterinary use in this context and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
Tesamorelin functions as a GHRH receptor (GHRH-R) agonist. In experimental models, binding to GHRH receptors on pituitary somatotrophs leads to:
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Stimulation of endogenous GH secretion
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Activation of cAMP/PKA signaling pathways
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Preservation of physiologic, pulsatile GH release
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Engagement of normal hypothalamic–pituitary feedback mechanisms
Unlike direct GH administration, tesamorelin is studied for its ability to promote physiologic GH production through upstream pituitary signaling.
Chemical Structure
Chemical Name:
Tesamorelin
Synonyms:
Tesamorelin acetate (common salt form)
Peptide Type:
Synthetic GHRH analog peptide
Peptide Length:
44 amino acids
Molecular Formula (peptide):
C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight (peptide):
~5,135.9 g/mol
CAS Number:
218949-48-5
Structural Description:
Tesamorelin is a linear peptide derived from the GHRH sequence with stabilizing modifications that enhance resistance to enzymatic degradation. Its extended peptide length and sequence optimization support sustained GHRH receptor activation in experimental research. Structural identification and sequence data corresponding to CAS 218949-48-5 are indexed in peptide supplier and chemical registry databases.
Note: Molecular weight and elemental composition may vary slightly depending on salt form (e.g., acetate). Values above refer to the peptide backbone.
Physical and Chemical Properties
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Appearance: White to off-white lyophilized powder
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Solubility: Soluble in water and buffered aqueous solutions after reconstitution
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Stability: Stable when stored lyophilized under cold, dry, and light-protected conditions
Research Focus Areas
Tesamorelin is commonly examined in laboratory research related to:
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Growth hormone secretion and pituitary signaling
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Hypothalamic–pituitary–somatotropic axis regulation
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Endocrine feedback and pulsatile hormone release models
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Comparative studies versus other GHRH analogs and GHRPs
Research Use Disclaimer
Tesamorelin is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
Tesamorelin is a synthetic GHRH analog peptide with verified chemical identification:
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CAS: 218949-48-5
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Peptide Length: 44 amino acids
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Molecular Formula (peptide): C₂₂₁H₃₆₆N₇₂O₆₇S
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Molecular Weight (peptide): ~5,135.9 g/mol
Its ability to stimulate endogenous GH release via pituitary signaling makes tesamorelin a key research compound for studies of growth hormone physiology and endocrine regulation.
| CAS Number | 218949-48-5 |
| Other Names | Egrifta, TH9507, 804475-66-9, TH 9507 |
| IUPAC Name | (4S)-4-[[2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2-[[(E)-hex-3-enoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-3-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-5-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid |
| Molecular Formula | C₂₂₁H₃₆₆N₇₂O₆₇S |
| Molecular Weight | 5136 |
