Survodutide Overview
Survodutide, also known by its development code BI 456906, is a synthetic peptide dual agonist of the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). It has been developed and studied in laboratory and clinical research for its integrated effects on appetite regulation, energy expenditure, and metabolic control.
In research contexts, survodutide is examined as part of the newer generation of dual-agonist metabolic peptides, distinct from GLP-1-only analogs due to its additional glucagon receptor activity.
Survodutide is not approved for human or veterinary use in this context and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
Survodutide functions as a dual receptor agonist, engaging two complementary metabolic signaling pathways:
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GLP-1 receptor agonism
Studied for effects on satiety signaling, glucose-dependent insulin pathways, and central appetite regulation. -
Glucagon receptor agonism
Studied for its role in increasing energy expenditure, lipid utilization, and hepatic metabolic signaling.
The combined GLP-1R/GCGR activity is investigated for synergistic metabolic effects not observed with single-pathway incretin peptides.
Chemical Structure
Chemical Name:
Survodutide
Synonyms:
Survodutide, BI 456906
Peptide Type:
Synthetic dual GLP-1 / glucagon receptor agonist peptide
Chemical Class:
Incretin-based metabolic peptide (dual agonist)
CAS Number:
2805997-46-8
Molecular Formula:
C₁₉₈H₃₀₈N₅₂O₆₀
(peptide backbone; modifications included)
Molecular Weight:
~4,200 g/mol
(approximate, sequence-dependent long peptide)
Structural Description:
Survodutide is a long-acting modified peptide engineered to balance GLP-1 and glucagon receptor activation. Like other modern incretin-based peptides, it incorporates structural modifications to enhance stability, receptor selectivity, and metabolic half-life. Structural identification corresponding to CAS 2805997-46-8 is indexed in chemical and supplier databases.
Physical and Chemical Properties
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Appearance: White to off-white lyophilized peptide
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Solubility: Soluble in water and buffered aqueous solutions after reconstitution
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Stability: Stable when stored lyophilized under cold, dry, and light-protected conditions
Research Focus Areas
Survodutide is commonly examined in laboratory and translational research related to:
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Dual GLP-1 / glucagon receptor signaling
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Energy expenditure and metabolic efficiency
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Appetite and body-weight regulation pathways
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Hepatic lipid metabolism and glucose handling
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Comparative studies versus GLP-1-only and other dual-agonist peptides
Research Use Disclaimer
Survodutide is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
Survodutide is a dual GLP-1/glucagon receptor agonist peptide with verified identification:
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CAS: 2805997-46-8
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Peptide Class: Dual incretin / glucagon agonist
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Structure: Long-acting modified peptide (BI 456906)
Its dual-pathway mechanism and defined chemical identity make survodutide a key research compound for studies of metabolic regulation, energy expenditure, and advanced incretin biology.
| CAS Number | 2805997-46-8 |
| Other Names | BI 456906; EX-A7878 |
| IUPAC Name | 18-[[4-[[2-[[(2R)-1-[[2-[[(2R)-1-[[2-[[2-[[(5R)-5-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[1-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]cyclobutanecarbonyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-carboxy-4-oxobutyl]amino]-18-oxooctadecanoic acid |
| Molecular Formula | C₁₉₈H₃₀₈N₅₂O₆₀ |
| Molecular Weight | 4231.692 g·mol−1 |
