SLU-PP-332

SLU-PP-332 Overview

SLU-PP-332 is a synthetic small-molecule agonist of estrogen-related receptor alpha (ERRα) developed and studied in academic research for its ability to drive mitochondrial biogenesis, oxidative metabolism, and energy-expenditure signaling. ERRα is a nuclear receptor that regulates genes involved in mitochondrial function and fatty-acid oxidation.

In laboratory research, SLU-PP-332 is widely cited as a chemical tool compound for studying endurance-like metabolic adaptations and skeletal-muscle energy pathways without direct adrenergic or hormonal stimulation.

SLU-PP-332 is not approved for human or veterinary use and is supplied strictly for laboratory and analytical research purposes.

Mechanism of Action

SLU-PP-332 functions as a selective ERRα agonist. In experimental systems, ERRα activation leads to:

• Upregulation of mitochondrial oxidative genes

• Increased fatty-acid oxidation and oxidative phosphorylation capacity

• Enhanced metabolic efficiency in skeletal muscle models

• Transcriptional activation of pathways overlapping with endurance exercise adaptations

Unlike AMPK activators or adrenergic agonists, SLU-PP-332 acts directly at the nuclear transcriptional level, making it a valuable probe for studying mitochondrial gene regulation.

Chemical Structure

Chemical Name:
SLU-PP-332

Synonyms:
SLU-PP-332

Chemical Class:
Estrogen-related receptor alpha (ERRα) agonist

Molecular Formula:
C₁₈H₁₄N₂O₂

Molecular Weight:
290.3 g/mol

CAS Number:
303760-60-3

PubChem CID:
163427913

Structural Description:
SLU-PP-332 is a fluorinated heteroaromatic small molecule designed to selectively activate ERRα. Its structure supports nuclear receptor binding and transcriptional activation of mitochondrial and oxidative metabolism genes. Structural identification and molecular data are indexed in PubChem and academic chemistry databases.

Physical and Chemical Properties

• Appearance: White to off-white solid

• Solubility: Soluble in DMSO and polar organic solvents; limited aqueous solubility

• Stability: Stable under dry, cool, and light-protected storage conditions

Research Focus Areas

SLU-PP-332 is commonly examined in laboratory research related to:

• Mitochondrial biogenesis and oxidative metabolism

• ERRα-dependent transcriptional regulation

• Skeletal-muscle endurance and energy-expenditure models

• Metabolic disease and exercise-mimetic research

Research Use Disclaimer

SLU-PP-332 is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.

Summary

SLU-PP-332 is a selective ERRα agonist with verified chemical identifiers:

• CAS: 303760-60-3

• Molecular Formula: C₁₈H₁₄N₂O₂

• Molecular Weight: 290.3 g/mol

• PubChem CID: 163427913

Its nuclear-receptor-driven mechanism and defined small-molecule structure make SLU-PP-332 a key research compound for studies of mitochondrial function, oxidative metabolism, and endurance-related signaling.