Seltorexant is a compound used in research laboratories. It is also known as JNJ-42847922 and seltorexantum. It falls under the category of selective orexin-2 receptor antagonists. The molecular structure contains a fluorine atom and a triazole ring. These features allow selective binding to OX2R over OX1R. Researchers use this compound in controlled in vitro studies. It helps examine receptor-ligand binding mechanisms. The compound is also used in cell-based assays. It serves as a tool for mapping receptor interactions. The compound is available in multiple formats for research flexibility. Kimera Chems supplies this product for research applications only. This product is not for clinical or medical use. All studies must be done in controlled in vitro laboratory environments.
Chemical Composition & Purity
The molecular formula of this compound is C₂₁H₂₂FN₇O. The molecular weight of the substance is 407.4 g/mol. Available formats:
- 1 gram powder
- 5 mg dry-fill capsules
- 30 mL liquid solution
The compound appears as a white to yellow solid. Kimera Chems verifies each batch for quality through third-party testing. They use high-performance liquid chromatography (HPLC) for analysis. This test confirms the compound’s identity and high purity level, which is ≥98%.
Research Applications
Seltorexant is studied for binding to OX2R proteins. The fluorine atom and triazole ring create a specific three-dimensional shape. This shape allows the compound to fit into the OX2R binding pocket. In radioligand assays, the compound competes with a tracer for the same site. The amount of tracer displaced shows binding strength. The same test with OX1R shows minimal displacement. This confirms OX2R selectivity.
- Binding assays: Measuring OX2R binding affinity and kinetics.
- Selectivity tests: Comparing OX2R versus OX1R binding.
- Protein binding: Measuring free fraction in plasma solutions.
Storage & Handling Protocol
If you want to preserve the compound’s stability, correct storage is important. That is why it is essential to follow standard laboratory protocols.
- Protect the product from light. Keep vials in dark environments.
- Protect the sample from moisture.
- Tightly close the container after each use.
- Use only sterile handling tools to prevent contamination.
Compliance & Usage Disclaimer
This product is for Research Use Only (RUO). It is a chemical for non-clinical laboratory analysis. It is not for human or animal consumption. It is not a drug or supplement. Any material offered as Seltorexant for sale is only for qualified institutions and professional researchers.
Availability & Research Sourcing
Kimera Chems is a professional source for high-quality research reagents. You can buy Seltorexant and other premium compounds from our website. We offer several formats to suit different laboratory needs. We also provide the necessary analytical data to support your compliance requirements.
| CAS Number | 1452539-75-1 |
| Other Names | Seltorexant, AIS8N3O50B, Seltorexantum, 2-(4,6-Dimethylpyrimidin-2-yl)-5-((2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)carbonyl)octahydropyrrolo(3,4-C)pyrrole Methanone, ((3aR,6aS)-5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo(3,4-C)pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)-, rel- |
| IUPAC Name | [(3aS,6aR)-2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone |
| Molecular Formula | C21H22FN7O |
| Molecular Weight | 407.4 |
| Dry-Fill Capsule Concentration | 5mg |
| Liquid Concentration And Solution | 10mg/ml |
