Selank Overview
Selank is a synthetic heptapeptide originally developed as an analog of the endogenous tetrapeptide tuftsin. It has been extensively studied in laboratory research for its effects on anxiolytic signaling, cognitive modulation, and neuroimmune pathways. Selank is structurally and mechanistically distinct from classical benzodiazepines and does not act as a direct GABA-A agonist.
In research contexts, Selank is commonly examined for stress-response modulation, memory-related signaling, and immune–neural interaction studies.
Selank is not approved for human or veterinary use in this context and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
Selank is studied as a multimodal neuromodulatory peptide. In experimental systems, it has been reported to:
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Modulate GABAergic signaling indirectly without benzodiazepine-site binding
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Influence serotonergic and dopaminergic pathways in stress-related models
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Affect neuroimmune signaling, including cytokine-related pathways
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Support cognitive and memory-related signaling under stress conditions
Its peptide nature and tuftsin-derived sequence make Selank a useful tool for studying non-sedative anxiolytic mechanisms and peptide-based neuromodulation.
Chemical Structure
Chemical Name:
Selank
Synonyms:
Selank peptide
Peptide Type:
Synthetic heptapeptide
Peptide Sequence:
Thr–Lys–Pro–Arg–Pro–Gly–Pro
Molecular Formula:
C₃₃H₅₇N₁₁O₉
Molecular Weight:
751.86 g/mol
CAS Number:
129954-34-3
Structural Description:
Selank is a linear heptapeptide composed of seven amino acids, derived from and extending the tuftsin motif. Its structure supports peptide stability and interaction with neurochemical and immune-related signaling pathways studied in laboratory research. Structural identification and molecular data are indexed in PubChem and peptide supplier databases.
Physical and Chemical Properties
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Appearance: White to off-white lyophilized powder
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Solubility: Soluble in water and buffered aqueous solutions after reconstitution
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Stability: Stable when stored lyophilized under cold, dry, and light-protected conditions
Research Focus Areas
Selank is commonly examined in laboratory research related to:
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Anxiolytic and stress-response signaling
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Cognitive and memory-related pathways
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Neuroimmune modulation
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Peptide-based neuromodulation research
Research Use Disclaimer
Selank is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
Selank is a well-characterized synthetic peptide with verified chemical identifiers:
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CAS: 129954-34-3
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Molecular Formula: C₃₃H₅₇N₁₁O₉
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Molecular Weight: 751.86 g/mol
Its non-sedative anxiolytic research profile and defined peptide structure make Selank a key compound for laboratory studies of stress modulation, cognitive signaling, and neuroimmune interaction.
| CAS Number | 129954-34-3 |
| Other Names | Selanc, TP-7, Thr-Lys-Pro-Arg-Pro-Gly-Pro, TP 7, UNII-TS9JR8EP1G, TS9JR8EP1G |
| IUPAC Name | (2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid |
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | 751.9 |
