SANA (MVD1) — 5-(2-Nitroethenyl)salicylic Acid
SANA (MVD1) is a novel nitroalkene derivative of salicylate under active investigation for its role in creatine-dependent thermogenesis. Supplied strictly for in vitro research and laboratory use. Not for human consumption.
What Is SANA (MVD1)?
SANA (MVD1) is the research designation for 5-(2-nitroethenyl)salicylic acid, a small-molecule nitroalkene built on a salicylate scaffold. It is currently the lead clinical candidate from Eolo Pharma and represents the first compound reported to pharmacologically activate creatine-dependent thermogenesis in adipose tissue.
Unlike incretin-based research tools (GLP-1, GIP, dual and triple agonists) that work primarily through appetite signaling, SANA is being studied for its ability to increase energy expenditure directly at the adipocyte level — a mechanistically distinct pathway in metabolic research.
SANA Mechanism of Action
In preclinical and Phase 1 literature, SANA (MVD1) has been characterized as:
- An upregulator of creatine metabolism genes and creatine kinase activity in adipose tissue
- A driver of ATP hydrolysis and futile creatine cycling, increasing heat output
- UCP1-independent — distinct from classical brown adipose thermogenesis
- AMPK-independent — does not rely on the canonical energy-sensor pathway
- Associated with preservation of lean mass in preclinical models, contrasting with the lean-mass loss signature of incretin agonists
This places SANA in a new mechanistic class for metabolic research, separate from existing receptor agonist or appetite-suppressant categories.
Research Applications
SANA (MVD1) is offered as a reference compound for laboratory investigation into:
- Creatine-dependent thermogenic pathways
- Adipocyte energy expenditure and substrate cycling
- Comparative metabolic research vs. incretin-class tool compounds
- Salicylate / nitroalkene structure-activity studies
- UCP1-independent thermogenesis models
Specifications
- Chemical name: 5-(2-Nitroethenyl)salicylic acid
- Research code: MVD1 / SANA
- Form: Lyophilized powder
- Purity: ≥98% (verified by third-party COA)
- Storage: Cool, dry, light-protected
Quality and Verification
Every lot of SANA (MVD1) ships with a third-party COA covering identity and purity. COAs are publicly accessible through our COA database so researchers can verify the exact lot before and after purchase.
Important Notice
SANA (MVD1) is sold strictly for in vitro research and laboratory use only (RUO). It is not a drug, supplement, food, or cosmetic and is not intended for human or veterinary use, ingestion, injection, or topical application. Purchase confirms acknowledgment of these terms.
| CAS Number | 42571-07-3 |
| IUPAC Name | 2-hydroxy-5-(2-nitroethenyl)benzoic acid |
| Molecular Formula | C9H7NO5 |
| Molecular Weight | 209.157 |
| Dry-Fill Capsule Concentration | 50mg |
