Nortadalafil is a research chemical. It is also known as Demethyltadalafil. This compound belongs to the phosphodiesterase type 5 (PDE5) inhibitor class. It is structurally related to tadalafil without the methyl group. Researchers study this compound for its interaction with PDE5 enzymes. The compound is also studied as a tadalafil-related impurity. Kimera Chems supplies this product for research applications only. All studies occur in controlled laboratory environments.
Chemical Composition & Purity
The molecular formula of this compound is C₂₁H₁₇N₃O₄. The molecular weight of this material is 375.38 g/mol. It appears as a white to off-white solid. Available formats:
- 1 gram powder
- 30 mL liquid solution
- 20 mg tablets (dry-fill capsules)
Kimera Chems verifies each batch through third-party testing. The analysis is done using high-performance liquid chromatography (HPLC). It confirms the compound’s identity and purity (≥98%).
Research Applications
Nortadalafil contains an amide bond and a piperazinedione ring in its structure. The molecule has multiple hydrogen bond donors and acceptors. These functional groups allow it to fit into the catalytic site of PDE5 enzymes. The benzodioxole ring contributes to the compound’s three-dimensional shape. In binding assays, researchers use isolated PDE5 enzyme preparations. A radiolabeled ligand is added to the system. Nortadalafil competes with this ligand for the same binding pocket. The amount of displacement indicates binding affinity. All the research is done in controlled in vitro settings.
- Binding studies: Measuring PDE5 enzyme interaction.
- Impurity profiling: Studying tadalafil synthesis by-products.
- Structure analysis: Comparing related compounds.
Storage & Handling Protocol
To maintain the stability of this compound, you need to store it properly by following the standard lab storage guidelines:
- Store powder in a cool, dry place.
- Refrigerate liquid solutions at 2-8°C.
- Keep the container sealed to prevent moisture absorption.
- Protect the product from direct light exposure.
- Use clean laboratory tools when handling the material to avoid contamination.
Compliance & Usage Disclaimer
This substance is for Research Use Only (RUO). It is not for human or animal consumption. This product is not a drug, medicine, or dietary supplement. Any Nortadalafil for sale is limited to trained investigators working under authorized institutions.
Availability & Research Sourcing
Kimera Chems supplies premium research compounds to the scientific community. You can buy Nortadalafil and other top-quality chemicals from our website.
| CAS Number | 171596-36-4 |
| Other Names | Demethyl Tadalafil |
| IUPAC Name | (2R,8R)-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione |
| Molecular Formula | C22H19N3O4 |
| Molecular Weight | 375.38 |
| Dry-Fill Capsule Concentration | Tablets, 20mg |
| Liquid Concentration And Solution | 20mg/mL PEG400, DMSO |
