GC-1 (Sobetirome) Overview
GC-1, also known as Sobetirome, is a synthetic small-molecule thyroid hormone analog developed to selectively activate thyroid hormone receptor beta (TRβ). In preclinical and clinical research settings, GC-1 has been investigated for its effects on lipid metabolism, cholesterol regulation, and metabolic signaling while minimizing activation of thyroid hormone receptor alpha (TRα), which is associated with undesirable cardiac and skeletal effects.
GC-1 (Sobetirome) is not approved for human or veterinary use and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
GC-1 functions as a selective agonist of thyroid hormone receptor beta (TRβ). Activation of TRβ influences transcriptional pathways involved in lipid metabolism, cholesterol transport, and energy expenditure. Due to its receptor selectivity, GC-1 has been studied as a tool compound for evaluating thyroid-mediated metabolic effects without the systemic stimulation typically associated with non-selective thyroid hormones.
Chemical Structure
Chemical Name:
4-Hydroxy-3-isopropylbenzyl-(4-hydroxy-3,5-dimethylphenyl)methane
Synonyms:
GC-1, Sobetirome
Molecular Formula:
C₂₂H₂₈O₃
Molecular Weight:
340.46 g/mol
CAS Number:
211555-08-7
Structural Description:
GC-1 is a non-iodinated thyroid hormone analog composed of substituted phenyl rings linked through a methylene bridge. The absence of iodine atoms differentiates it from endogenous thyroid hormones while preserving receptor beta selectivity. Structural data and identification are available via PubChem.
Physical and Chemical Properties
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Appearance: White to off-white crystalline powder
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Solubility: Poor aqueous solubility; soluble in common organic solvents
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Stability: Stable under dry, cool, and light-protected storage conditions
Research Focus Areas
GC-1 (Sobetirome) is commonly investigated in laboratory research related to:
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Thyroid hormone receptor beta signaling
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Lipid metabolism and cholesterol regulation
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Metabolic and energy expenditure pathways
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Selective thyroid hormone analog development
Research Use Disclaimer
GC-1 (Sobetirome) is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
GC-1 (Sobetirome) is a selective thyroid hormone receptor beta agonist with a well-defined small-molecule structure. Its receptor selectivity and non-iodinated scaffold make it a valuable compound for metabolic and lipid research models focused on thyroid-mediated signaling.
| CAS Number | 211110-63-3 |
| Other Names | GC 1 compound | GC-1 | QRX-431 |
| IUPAC Name | 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-acetic acid |
| Molecular Formula | C20H24O4 |
| Molecular Weight | 328.4 |
| Dry-Fill Capsule Concentration | NA |
| Liquid Concentration And Solution | 200mcg/ml (PEG-400, DMSO) |
| Aliquot Concentration And Solution | NA |
