Aminotadalafil Article
What Is Aminotadalafil?
Aminotadalafil is a structural analog of tadalafil, modified with an amino functional group on the core scaffold. This substitution alters physicochemical characteristics while retaining relevance to phosphodiesterase type 5 (PDE5) research. Aminotadalafil is commonly referenced in structure–activity relationship (SAR) studies examining how functional group changes influence PDE5 binding affinity, selectivity, and metabolic behavior in controlled laboratory settings.
This compound is not an approved pharmaceutical and is supplied strictly for research and analytical purposes.
Chemical & Physical Properties
| Property | Description |
|---|---|
| Compound Class | PDE5 inhibitor analog |
| Chemical Family | β-Carboline-derived tadalafil analog |
| Functional Group | Primary amine substitution |
| Molecular Nature | Small-molecule synthetic compound |
| Appearance | Typically white to off-white crystalline powder |
| Solubility | Poorly soluble in water; soluble in DMSO, DMF, and select organic solvents |
| Stability | Stable under dry, cool, light-protected conditions |
Note: Exact analytical values (MW, melting point, spectral data) should be verified against batch-specific COA documentation.
Mechanism of Research Interest
In research models, Aminotadalafil is studied for its interaction with PDE5, the enzyme responsible for cyclic guanosine monophosphate (cGMP) degradation. By modifying the tadalafil backbone with an amino group, researchers can evaluate:
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PDE5 binding behavior and selectivity shifts
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SAR comparisons versus tadalafil and other analogs
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Enzyme inhibition kinetics in vitro
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Metabolic stability and structural tolerance studies
These properties make Aminotadalafil useful in comparative pharmacology and medicinal chemistry research.
Common Research Applications
Aminotadalafil is utilized in laboratory environments for:
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PDE5 inhibition assays
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SAR and analog screening programs
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Computational docking and modeling validation
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Reference material in analytical method development
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Comparative enzymatic studies versus tadalafil derivatives
Handling & Storage Guidelines
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Store in a cool, dry environment
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Protect from light and moisture
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Use appropriate laboratory PPE during handling
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Dissolve using validated solvent systems suitable for PDE5 analogs
Research Use Disclaimer
Aminotadalafil is sold strictly for research use only (RUO). Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.
Frequently Asked Questions
Is Aminotadalafil the same as tadalafil? No. Aminotadalafil is a structural analog, not tadalafil itself. The amino substitution alters its chemical behavior and research relevance.
Is Aminotadalafil FDA approved? No. Aminotadalafil is not an approved drug and is supplied solely for laboratory research.
Why is Aminotadalafil used in research? It allows researchers to study how functional group modifications affect PDE5 interaction, selectivity, and molecular behavior.
| CAS Number | 385769-84-6 |
| IUPAC Name | (2R,8R)-6-amino-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione |
| Molecular Formula | C21H18N4O4 |
| Molecular Weight | 390.39 g/mol |
| Dry-Fill Capsule Concentration | 5mg, 20mg |
| Liquid Concentration And Solution | 20mg/ml PEG400, DMSO |
| Aliquot Concentration And Solution | NA |
