AICAR is a research compound also known as AICA ribonucleotide or acadesine. It falls under the category of aminoimidazole carboxamide ribonucleotide. This classifies it as an analog of purine nucleosides. Researchers study this compound for its role in cellular energy pathways. In particular, scientists study its interaction with the AMP-activated protein kinase (AMPK) pathway. This pathway is a central regulator of cell energy. Researchers use AICAR in in vitro models to examine these molecular interactions. They analyze how this chemical may mimic the cellular signal of low energy.
Chemical Composition & Purity
AICAR is supplied as a solid, lyophilized powder. It appears as a white to light yellow substance. Its molecular formula is C₉H₁₄N₄O₅. Kimera Chems subjects each batch to stringent quality control. High-performance liquid chromatography (HPLC) is the primary analytical method used in third-party testing to ensure compound purity that is ≥98%. This high level of purity is critical for generating consistent data. It ensures that experimental results are reliable and reproducible.
Research Applications
AICAR serves as a cell-permeable activator in laboratory experiments. Researchers study its interaction with the AMPK signaling complex. The compound is an analog of adenosine monophosphate (AMP). Scientists use it to examine AMPK pathway activation in cultured cells. This study contributes to the mapping of cell energy-sensing mechanisms. Investigations focus on molecular associations, not physiological outcomes.
- AMPK Pathway Studies: Examining kinase activation mechanisms.
- Cellular Metabolism Research: Use in metabolic flux analysis.
- Energy Sensing Models: Studying low-energy signal mimicry.
- In Vitro Assay Development: As a reference compound.
- Comparative Signaling Analysis: Alongside other pathway modulators.
Storage & Handling Protocol
Proper storage is essential to maintain compound stability. Follow all standard laboratory safety procedures. This preserves the material for future research use.
- Store the dry powder at -20°C for long-term stability.
- Keep it in a dry place; this prevents it from humidity.
- Store in an amber vial or opaque container.
- Keep the powder in a tightly closed vial.
- Wear gloves and masks to prevent sample contamination during weighing.
Compliance & Usage Disclaimer
AICAR peptide is for Research Use Only (RUO). Scientists must not use this material for human or animal consumption. It is not a dietary supplement or drug. Researchers are responsible for following local laws when they search for aicar peptide for sale.
Availability & Research Sourcing
Kimera Chems supplies high-purity research chemicals. Scientists can buy AICAR peptide, SARMs, nootropics and amino acids for various research studies.
| CAS Number | 2627-69-2 |
| Other Names | AICA ribonucleotide 4-carboxy-5-aminoimidazole ribotide 5′-phosphoribosyl-5-amino-4-imidazolecarboxamide 5-amino-4-imidazolecarboxamide ribofuranoside 5′-monophosphate AICAR AICAriboside 5′-monophosphate Z-nucleotide ZMP aminoimidazole carboxamide ribonucleotideAICA ribonucleotide 4-carboxy-5-aminoimidazole ribotide 5′-phosphoribosyl-5-amino-4-imidazolecarboxamide 5-amino-4-imidazolecarboxamide ribofuranoside 5′-monophosphate AICAR AICAriboside 5′-monophosphate Z-nucleotide ZMP aminoimidazole carboxamide ribonucleotide |
| IUPAC Name | 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, Acadesine, N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide |
| Molecular Formula | C9H14N4O5 |
| Molecular Weight | 258.23 |
