Acetildenafil – Research Compound Overview
Acetildenafil is a synthetic analog of sildenafil developed as a phosphodiesterase type 5 (PDE5) inhibitor reference compound for laboratory and analytical research. Structurally related to sildenafil, acetildenafil features an acetylated modification that alters molecular weight and polarity, making it useful for comparative PDE5 inhibition studies, analytical method validation, and reference standard development.
Acetildenafil has been detected historically in forensic and analytical contexts, increasing its relevance for LC-MS, HPLC, and structural elucidation research involving PDE5 inhibitor analogs.
This compound is supplied strictly for research use only (RUO) and is not intended for human or veterinary use.
Chemical & Technical Properties
| Property | Description |
|---|---|
| Chemical Name | Acetildenafil |
| CAS Number | 831217-01-7 |
| Molecular Formula | C₂₅H₃₄N₆O₄S |
| Molecular Weight | ~518.64 g/mol |
| Compound Class | PDE5 inhibitor analog |
| Structural Relation | Sildenafil analog (acetylated derivative) |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in DMSO; limited aqueous solubility |
| Stability | Stable under dry, cool, light-protected conditions |
Research Applications
Acetildenafil is commonly utilized in non-clinical laboratory research, including:
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PDE5 inhibitor structure-activity relationship (SAR) studies
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Analytical reference material for sildenafil analog identification
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HPLC and LC-MS method development
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Comparative binding and enzymatic inhibition assays
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Forensic and contaminant screening research
Its close structural similarity to sildenafil makes acetildenafil valuable in analytical differentiation and analog detection workflows.
Handling & Storage Recommendations
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Store in a cool, dry environment
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Protect from light and moisture
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Avoid repeated heat exposure
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Use appropriate laboratory PPE during handling
Regulatory & Research Use Disclaimer
Acetildenafil is sold strictly for laboratory research purposes only.
Not for human consumption, medical use, veterinary use, or dietary supplementation.
No therapeutic claims are made or implied.
| CAS Number | 831217-01-7 |
| Other Names | Hongdenafil, 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[2-(4-ethyl-1-piperazinyl)acetyl]phenyl]-1,6-dihydro-1-methyl-3-propyl- |
| IUPAC Name | 5-[2-ethoxy-5-[2-(4-ethyl-1-piperazinyl)acetyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one |
| Molecular Formula | C25H34N6O3 |
| Molecular Weight | 466.58 |
| Dry-Fill Capsule Concentration | 30mg |
| Liquid Concentration And Solution | NA |
| Aliquot Concentration And Solution | NA |
