3,5-Diiodo-L-thyronine (T2) Overview
3,5-Diiodo-L-thyronine (T2) is a naturally occurring metabolite of thyroid hormones, derived from thyroxine (T4) and triiodothyronine (T3) through deiodination pathways. Unlike T3 and T4, T2 is studied primarily for its non-genomic and mitochondrial effects in laboratory research.
In experimental contexts, T2 is examined for its role in energy metabolism, lipid utilization, and mitochondrial function, making it a compound of interest in thyroid hormone metabolism and bioenergetics research.
3,5-Diiodo-L-thyronine is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
T2 is studied as a thyroid hormone metabolite with rapid, non-genomic activity. In research models, it has been associated with:
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Stimulation of mitochondrial oxidative metabolism
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Enhancement of fatty-acid β-oxidation
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Modulation of energy expenditure independent of classical nuclear thyroid hormone receptor activation
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Interaction with mitochondrial respiratory chain components
These properties distinguish T2 from T3, which primarily exerts genomic effects via nuclear thyroid hormone receptors.
Chemical Structure
Chemical Name:
3,5-Diiodo-L-thyronine
Synonyms:
3,5-T2, Diiodothyronine (3,5-)
Chemical Class:
Iodinated thyroid hormone metabolite
Molecular Formula:
C₁₅H₁₃I₂NO₄
Molecular Weight:
525.09 g/mol
CAS Number:
1041-01-6
Structural Description:
3,5-Diiodo-L-thyronine consists of a thyronine backbone with two iodine atoms substituted at the 3 and 5 positions on the phenolic ring. This iodination pattern underlies its distinct metabolic activity compared to T3 and T4. Structural identification corresponding to CAS 1041-01-6 is indexed in chemical and biochemical registry databases.
Physical and Chemical Properties
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Appearance: White to off-white crystalline solid
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Solubility: Slightly soluble in water; soluble in organic solvents and alkaline solutions
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Stability: Stable under dry, cool, and light-protected storage conditions
Research Focus Areas
3,5-Diiodo-L-thyronine (T2) is commonly examined in laboratory research related to:
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Thyroid hormone metabolism and deiodination pathways
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Mitochondrial function and oxidative phosphorylation
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Lipid metabolism and energy-expenditure signaling
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Non-genomic thyroid hormone actions
Research Use Disclaimer
3,5-Diiodo-L-thyronine (T2) is intended for research use only.
Not for human consumption, therapeutic use, or diagnostic application. All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
Summary
3,5-Diiodo-L-thyronine (T2) is a thyroid hormone metabolite with verified chemical identifiers:
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CAS: 1041-01-6
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Molecular Formula: C₁₅H₁₃I₂NO₄
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Molecular Weight: 525.09 g/mol
Its distinct iodination pattern and mitochondrial-focused research profile make T2 a valuable compound for studies of thyroid signaling, bioenergetics, and metabolic regulation.
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| CAS Number | 1041-01-6 |
| Other Names | -(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine; 3-[4-(p-Hydroxyphenoxy)-3,5-diiodophenyl]-L-alanine; L-T2 |
| IUPAC Name | 2-amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid |
| Molecular Formula | C15H13I2NO4 |
| Molecular Weight | 525.08 |
| Dry-Fill Capsule Concentration | 250mcg |
| Liquid Concentration And Solution | 500mcg/ml (Propylene Glycol, DMSO) |
